Table 2:
Disease progression markers in amnestic patients with MCI
| Markers of Disease Progression | Characteristics | Procedure(s)a | Approximate Cost (in US dollars)b |
|---|---|---|---|
| Structural neuroimaging with vMRI | Medial temporal lobe and/or neocortical atrophy; white matter abnormalities may also be present | 1) Noncontrast MRI brain CPT 70551 | 1) 437.20 (365.75f+71.45g) |
| 2) 3D quantitative segmental volume reporting and assessmentc CPT 76377 | 2) 82.68 (44.57f+38.11g) | ||
| FDG-PET | Temporoparietal hypometabolism | Brain imaging (PET) metabolic evaluation CPT 78608 | 1266.40 (1041.99f+150i+74.41g) |
| Amyloid imaging | Increased uptake in frontal, parietal, and/or temporal regions | PET imaging limited area CPT 78811 | 2721.83 (1041.99f+1600i+79.84g) |
| CSF amyloid | Decreased | 1) CSF lumbar puncture CPT 62270 | 1) 242.58 (78.93h+163.65g) |
| CSF tau (total tau) | Increased | 2) CSF analysis and interpretationd CPT 83520 | 2) 1080 |
| APOE ϵ4 carrier status | Dose-dependent effect (risk for AD: ϵ4/ϵ4 > ϵ3/ϵ4 > ϵ3/ϵ3 > ϵ3/ϵ2 > ϵ2/ϵ2) | 1) Buccal swab or routine venipuncture CPT 36415 | 1) 3 |
| 2) APOE genotype analysis and interpretatione CPT 81401 | 2) 500 |
Note:—APOE ϵ4 indicates apolipoprotein E4; CPT, Current Procedural Terminology; vMRI, volumetric-based MR imaging.
Determined using data from the Centers for Medicare and Medicaid Services (www.cms.gov). For informational purposes only. Selected CPT code may vary.
Determined, when possible, using National Payment Amount data from the Centers for Medicare and Medicaid Services (www.cms.gov). For informational purposes only. Payment amount varies by location.
Using NeuroQuant (http://www.cortechs.net/products/neuroquant.php).
Using the ADmark Phospho-Tau/Total-Tau/Ab42 CSF Analysis & Interpretation (Symptomatic) test (http://www.athenadiagnostics.com/content/test-catalog/find-test/service-detail/q/id/311).
Using the ADmark ApoE Genotype Analysis & Interpretation (Symptomatic) (http://www.athenadiagnostics.com/content/test-catalog/find-test/service-detail/q/id/35).
Approximate technical charge.
Approximate professional charge.
Approximate facility price.
Approximate ligand price.