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. Author manuscript; available in PMC: 2014 Jul 30.
Published in final edited form as: Nature. 2013 Nov 27;505(7485):691–695. doi: 10.1038/nature12862

Extended Data Figure 8. Role for cGAS in BMMO activation.

Extended Data Figure 8

a, BMMO from wild-type and cGas−/− mice were analysed for baseline expression of chemokines Ccl5 and Cxcl10 by RT–PCR. b, BMMO from wild-type and cGas−/− mice were treated with polyIC (pIC) or transfected with polyIC (Tf-pIC) and Ifnb and Ifit1 levels were determined by qRT–PCR. In both panels, gene expression levels are relative to the housekeeping gene RPS29 and normalized to mock-treated wild-type cells. Data represent two experiments performed in triplicate. Error bars represent s.d. Statistical significance was determined by t-test. *P <0.05, **P <0.01, ***P <0.001.