Table 2. Biochemical parameters (Mean±SD) #of the db/db mice with or without dietary selenate supplementation.
| Parameter | DMCtrl | DMSe | P Value |
| Blood | |||
| Pretreatment: HbA1c [%(mmol/mol)] | 4.2±0.3(21±2) | 4.0±0.5(20±6) | |
| At sacrifice: HbA1c [%(mmol/mol)] | 5.9±0.6(41±6) | 4.4±0.5(25±5)** | 0.00516 (0.00331) |
| Plasma | |||
| glucose, mmol/L | 29.26±6.52 | 15.99±5.21*** | 0.00097 |
| Insulin, pmol/L | 11.78±1.67 | 21.44±8.16* | 0.01640 |
| HOMA-IR index | 16.56±3.12 | 13.56±1.91NS | 0.09395 |
| triglycerides, mmol/L | 1.18±0.39 | 0.61±0.22* | 0.04155 |
| cholesterol, mmol/L | 2.74±0.22 | 3.61±0.60* | 0.04061 |
| low-density lipoprotein, mmol/L | 1.91±0.08 | 2.21±0.23* | 0.01206 |
| malondialdehyde, mmol/L | 3.71±0.73 | 2.72±0.73NS | 0.06013 |
| Pancreatic tissue homogenate | |||
| Insulin, pmol/mg protein | 282.20±57.24 | 366.25±58.48* | 0.01668 |
#
Mean±SD were calculated for five animals in the DMCtrl group and eight animals in the DMSe group.
*Values significantly different from DMCtrl mice, by the Student t test (*P<0.05, **P<0.01, *** P<0.001).
NS
indicates the values were not significantly different from DMCtrl mice by the Student t test (P>0.05).