Table 2. Summary of associations between 8 SNPs in ZFHX3 and the risk of AF.

SNP	Position	Minor/major allele	Casesa	Controlsa	MAF(cases)	MAF(controls)	P HWE	OR(95%CI) b	P b	P FDR c
rs12596992	71536544	C/G	96/252/236	132/458/382	0.38	0.37	0.78	1.08(0.93–1.26)	0.316	0.316
rs13336412	71539450	A/C	124/297/173	195/500/301	0.46	0.45	0.62	1.1(0.94–1.27)	0.23	0.263
rs16971312	71413345	G/A	43/226/326	78/426/492	0.26	0.29	0.28	0.85(0.72–1.00)	0.056	0.112
rs16971436	71550264	G/T	3/71/523	11/152/833	0.06	0.09	0.18	0.74(0.56–0.98)	0.039	0.104
rs17680796	71538441	T/C	60/266/268	84/438/472	0.32	0.3	0.21	1.15(0.98–1.35)	0.09	0.144
rs6499600	71536875	T/C	75/275/244	164/506/317	0.36	0.42	0.11	0.73(0.63–0.86)	1.07×10−4	4.28×10−4
rs2106261	71609121	A/G	110/299/184	99/446/451	0.44	0.32	0.46	1.71(1.46–2.00)	1.85×10−11	1.48×10−10
rs8049936	71642787	G/A	61/246/284	114/435/447	0.31	0.33	0.6	0.9(0.77–1.05)	0.175	0.233

SNP, single nucleotide polymorphism; AF, atrial fibrillation; MAF, minor allele frequency; P _HWE, P values for Hardy–Weinberg equilibrium tests in control groups; OR odds ratio; CI confidence interval.

^aIndividuals homozygous for the minor allele/heterozygous/homozygous for the major allele.

^bOR (95%CI) and P values were derived from logistic regression analysis in the additive model adjusting for age, gender, hypertension, diabetes and coronary artery disease.

^cMultiple comparisons P values for false discovery rate.