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. 2014 May 10;9:10. doi: 10.1186/1749-8104-9-10

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Copyright © 2014 Opperman and Grill; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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rpm-1 and syd-2 regulate synapse formation in GABAergic motor neurons. (A) Schematic of a DD motor neuron innervating dorsal muscle cells (inspired by Worm Atlas). Green triangles represent presynaptic terminals. P_unc-25SNB-1::GFP (juIs1) was visualized with epifluorescent microscopy for the indicated genotypes. The dorsal cord has gaps (arrow) and aggregated presynaptic terminals (arrowhead) in rpm-1 mutants. (B) Schematic of VD motor neuron innervating ventral muscle cells. Green triangles represent presynaptic terminals. SNB-1::GFP was visualized with epifluorescent microscopy for the indicated genotypes. The ventral cord has gaps (arrow) and aggregated presynaptic terminals (arrowhead) in rpm-1 mutants. In A and B, defects are enhanced in rpm-1; syd-2 double mutants. Analysis was performed on young adults grown at 25°C. DD, dorsal D neuron; VD, ventral D neuron. Scale bar, 10 μm.