Table 2.

Comparison of various measurements (symbols are same as in table 1) between WT and β4KO on control, Alk, or Acid diets and treated with vehicle (veh), hydrochlorothiazide (HCTZ), or amiloride (amil).

	KW		V		U[K]		U[Na]		P[K]		P[Na]		Uosm		Posm		Hct.		UpH
units	mgm	N	ml/day	N	mM	N	mM	N	mM	N	mM	N	mOsm/L	N	mOsm/L	N	%	N		N
WT-veh	275	4	1.3	4	298	4	62.3	4	4.32	4	158.1	4	2180	4	277.5	4	40.8	4	6.17	4
±SEM	10		0.24		82.3		5		0.15		0.8		410		2.5		1.5		0.09
WT-HCTZ	273	8	1.66	7	282	7	137.9	7	4.19	8	154.9	7	2141	7	297.5	8	42.6	3	6.24	7
±SEM	11		0.27		66.9		35.5		0.11		1.7		440		4.9		1.9		0.19
WT-amil	282	4	2.4	4	110	4	244.5	4	5.81	4	140.3	4	1670	4	282.5	4	46.7	4	6.3	4
±SEM	8		0.35		39		20.9		0.22		1.6		385		2.5		1.9		0.11
WT-Alk-veh	276	9	2	9	716	9	4.44	9	5.62	9	147.4	7	2339	9	291.1	9	40.4	9	7.31	9
±SEM	8		0.34		93.4		1.01		0.23		1.6		376		3.1		1.1		0.32
WT-Alk-HCTZ	274	4	2.15	4	487	4	3.55	4	4.89	4	146.9	4	1647	4	277.5	4	42.9	4	7.18	4
±SEM	10		0.35		75.5		0.76		0.21		2.1		145		2.5		1.6		0.51
WT-Alk-amil	256	8	1.78	8	282	6	184.2	8	7.2	8	135.7	8	1657	8	280	8	49.2	7	6	8
±SEM	1		0.18		37		17.5		0.05		0.8		201		2.7		1		0.25
KO-Alk-veh	248	7	1,61	7	373	7	4.79	7	5.67	7	150	6	1769	7	284	7	39	7	6.32	7
±SEM	14		0.24		94		0.95		0.28		2		280		3.7		0.8		0.25
KO-Alk-HCTZ	244	5	1.8	4	253	4	4.01	4	5.04	5	148.3	4	1225	4	302	5	38.3	3	6.34	4
±SEM	8		0.11		35		0.64		0.37		1.1		118		4		1.9		0.08
KO-Alk-amil	225	5	0.64	5	528	5	448	5	7.55	5	132.5	5	3137	5	290	5	47.2	4	6.25	5
±SEM	3		0.02		63.6		24.9		0.63		1		409		3.2		1.2		0.14