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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Ann Neurol. 2014 May 28;75(6):837–850. doi: 10.1002/ana.24139

Figure 6.

Figure 6

Glial activation in the SDH of ‘pain-positive’ HIV-1 patients and i.t. gp120 mice. A. Immunoblots of GFAP, Iba1, TNFα and IL-1β in the SDH of human patients (left panel) and i.t. gp120 mice at day 7 (7D), 14D or 21D (right panel). GFAP was increased both in the ‘pain-positive’ HIV patients and i.t. gp120 mice. Iba1 was not increased in the ‘pain-positive’ HIV-1 patients but was up-regulated in the i.t. gp120 mice. TNFα and IL-1β were significantly increased in the ‘pain-positive’ HIV-1 patients and i.t. gp120 mice. B-E. Quantitative summary (human patient specimens: 5/group; mice: 6/group. The same sample sizes were used in Fig. 7 and Fig. 8) of GFAP (B), Iba1 (C), TNFα (D) and IL-1β (E). For mice used in this and subsequent figures, i.t. injection of gp120 was performed following the paradigm indicated in Fig. 3. (*, p<0.05; **, p<0.01; ***, p<0.001; One-way ANOVA).