Table 4.

CHC Treatment Parameters

Model Parameter	Base Case Value (Range)	References
SVR Rates
SOF/RBV
F0-F4	0.70 (0.52–0.84)	(7–10)
SOF/SMV
Q80K+
F0-F2	0.89 (0.80–0.98)	(13)
F3-F4	0.91 (0.82–0.98)	(13)
Q80K-
F0-F4	0.98 (0.88–0.98)	(13)
SOF/LDV
F0-F4	0.96 (0.90–0.98)	(27)
Re-treatment
Proportion re-treated after initial treatment failure	0.90 (0.80–1.0)	Estimation
Disease Progression after SVR (annual rates)
F3 SVR to decompensated cirrhosis	0.0010 (0.0008–0.0012)	(28, 36)
F3 SVR to HCC	0.007 (0.006–0.008)	(28, 36)
F4 SVR to decompensated cirrhosis	0.003 (0.002–0.004)	(28, 36)
F4 SVR to HCC	0.019 (0.015–0.023)	(28, 36)
Fibrosis Regression after SVR (proportions)
F3 to F2	0.50 (0.25–0.82)	(22–24, 26)
F4 to F2	0.08 (0.06–0.10)	(25)
F4 to F3	0.34 (0.19–0.49)	(22, 24, 26)

Abbreviations: CHC = chronic hepatitis C; F0-F4 = Metavir fibrosis stages; HCC = hepatocellular carcinoma; LDV = ledipasvir; RBV = ribavirin; SMV = simeprevir; SOF = sofosbuvir; SVR = sustained virologic response

Values in tables have been rounded. For full decimal places, consult cited sources.