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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Nanomedicine. 2014 Feb 22;10(5):1003–1012. doi: 10.1016/j.nano.2014.02.002

Figure 6.

Figure 6

Targeting of EL-NPs in vascular calcification model (A) VVG histological stain for rat aorta after 3 weeks of warfarin + vitamin K (WK) treatment (arrow marks indicate fragmented elastin fibers, black) (B) healthy rat aorta. (C) IVIS imaging of whole heart and aorta at 24 hours after intravenous injection of EL-NPs. Strong fluorescent signal indicates the localization of ELNPs at specific sites of elastic lamina fragmentation. (D) Targeting of EL-NPs in healthy Vs. WK animals at 24 hours after intravenous injection showing significantly higher fluorescence in the aortic arch (n=6).