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Application of the chemokine SDF-1 increased intracellular calcium concentration in DRG sensory neurons in HFD-induced diabetes. Representative trace of intracellular calcium responses of acutely cultured DRG sensory neurons from RD mice (A) and HFD mice (B) indicating a response to SDF-1 in diabetic DRG. Response to high K + (50 mM) and to capsaicin as positive control is also shown in RD (A) and HFD DRG (B).
