TABLE 3.
The influence of investigated polymorphisms on liver and gastrointestinal (GI) toxicity (N = 41)
| Gene | Polymorphism | Liver toxicitya | GI toxicitya | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| N (%) | OR (95 % CI) | p | N (%) | OR (95 % CI) | p | |||
| MTHFR | rs1801133 | CC | 10 (45.5) | Reference | 6 (27.3) | Reference | ||
| CT+TT | 14 (73.7) | 3.37 (0.90–12.6) | 0.072 | 5 (26.3) | 0.95 (0.24–3.81) | 0.945 | ||
| rs1801131 | AA | 10 (58.8) | Reference | 5 (29.4) | Reference | |||
| AC+CC | 14 (58.3) | 0.98 (0.28–3.46) | 0.975 | 6 (25.0) | 0.80 (0.20–3.22) | 0.754 | ||
| MTHFD1 | rs2236225 | GG | 7 (46.7) | Reference | 5 (33.3) | Reference | ||
| GA+AA | 17 (65.4) | 2.16 (0.59–7.90) | 0.245 | 6 (23.1) | 0.60 (0.15–2.46) | 0.477 | ||
| TYMS | rs34743033 | 2R/2R | 7 (50.0) | Reference | 2 (14.3) | Reference | ||
| 2R/3R+3R/3R | 17 (63.0) | 1.7 (0.46–6.28) | 0.426 | 9 (33.3) | 3.00 (0.55–16.38) | 0.205 | ||
| MTRR | rs1801394 | AA | 6 (66.7) | Reference | 1 (11.1) | Reference | ||
| AG+GG | 18 (56.3) | 0.64 (0.14–3.04) | 0.577 | 10 (31.3) | 3.64 (0.40–33.12) | 0.252 | ||
| MTR | rs1805087 | AA | 15 (60.0) | Reference | 5 (20.0) | Reference | ||
| AG+GG | 9 (56.3) | 0.86 (0.24–3.06) | 0.812 | 6 (37.5) | 2.40 (0.59–9.82) | 0.223 | ||
| SLC19A1 | rs1051266 | GG | 6 (50.0) | Reference | 4 (33.3) | Reference | ||
| GA+AA | 18 (62.1) | 1.64 (0.42–6.36) | 0.477 | 7 (24.1) | 0.64 (0.15–2.77) | 0.547 | ||
| SLCO1B1 | rs2306283 | AA | 9 (81.8) | Reference | 3 (27.3) | Reference | ||
| AG+GG | 15 (50.0) | 0.22 (0.04–1.21) | 0.081 | 8 (26.7) | 0.97 (0.21–4.59) | 0.696 | ||
| rs4149056 | TT | 17 (73.9) | Reference | 4 (17.4) | Reference | |||
| TC+CC | 7 (38.9) | 0.23 (0.06–0.85) | 0.028 | 7 (38.9) | 3.02 (0.72–12.70) | 0.131 | ||
| rs11045879 | TT | 18 (75.0) | Reference | 5 (20.8) | Reference | |||
| TC+CC | 6 (35.3) | 0.18 (0.05–0.71) | 0.014 | 6 (35.3) | 2.07 (0.51–8.41) | 0.308 | ||
| ABCB1 | rs2032582 | GG | 5 (55.6) | Reference | 2 (22.2) | Reference | ||
| GT+GA+TT+AA | 19 (59.4) | 1.17 (0.26–5.20) | 0.837 | 9 (28.1) | 1.37 (0.24–7.88) | 0.725 | ||
| rs1045642 | CC | 6 (66.7) | Reference | 0 (0.0) | Reference | |||
| CT+TT | 20 (57.1) | 0.67 (0.11–4.13) | 0.663 | 11 (31.4) | / | 0.167b | ||
| ABCC2 | rs2804402 | CC | 8 (88.9) | Reference | 3 (33.3) | Reference | ||
| CT+TT | 16 (50.0) | 0.13 (0.01–1.12) | 0.063 | 8 (25.0) | 0.67 (0.14–3.30) | 0.619 | ||
| rs717620 | GG | 15 (55.6) | Reference | 3 (11.1) | Reference | |||
| GA+AA | 9 (64.3) | 1.44 (0.38–5.45) | 0.591 | 8 (57.1) | 10.67 (2.15–52.85) | 0.004 | ||
| rs2273697 | GG | 17 (73.9) | Reference | 6 (26.31) | Reference | |||
| GA+AA | 7 (38.9) | 0.23 (0.06–0.85) | 0.028 | 5 (27.8) | 1.09 (0.27–4.37) | 0.903 | ||
| ABCG2 | rs2231142 | CC | 17 (56.7) | Reference | 10 (33.3) | Reference | ||
| CA+AA | 7 (63.6) | 1.34 (0.32–5.56) | 0.689 | 1 (9.1) | 0.20 (0.02–1.79) | 0.150 | ||
a
calculated using logistic regression;
b
calculated using Fisher’s exact test as there were no patients in one group