TABLE 1.
Characteristics of the included studies about focal colorectal incidental uptake detected by 18F-FDG PET or PET/CT
| Authors | Year | Country | Device used | No. of patients evaluated | No. of patients with FCIs | No. of FCIs | No. of FCIs verified by colonoscopy or histology |
Final diagnosis of FCIs
|
Average SUV in FCIs
|
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Malignant | Pre-malignant | Benign | No lesions identified | Malignant FCIS | Pre-malignant FCIs | Benign FCIs | ||||||||
| Zhuang H et al. | 2002 | USA/Brazil | PET | 197 | 17 | 17 | 14 | 5 | 1 | 8 | n.a. | n.a. | n.a. | |
| Tatlidil R et al. | 2002 | USA | PET | 3000 | n.a. | n.a. | 13 | 6 | 4 | 3 | 0 | n.a. | n.a. | n.a. |
| Chen YK et al. | 2003 | Taiwan | PET | 3210 | 22 | 23 | 23 | 6 | 17 | 0 | 0 | 5.74 ± 2.26* | 3.56 ± 0.68* | n.a. |
| Pandit-Taskar N et al. | 2004 | USA | PET | 1000 | n.a | n.a. | 10 | 1 | 7 | 0 | 2 | 13.6 | 7.0 ± 3.0 | n.a. |
| Agress H et al. | 2004 | USA | PET | 1750 | n.a. | n.a. | 27 | 3 | 18 | 3 | 3 | n.a | n.a | n.a. |
| Kamel EM et al. | 2004 | Switzerland | PET/CT | 3281 | n.a. | n.a. | 54 | 9 | 27 | 9 | 9 | n.a | n.a | n.a. |
| Lardinois D et al. | 2005 | Switzerland/Russia | PET/CT | 350 | 11 | 11 | 11 | 0 | 8 | 3 | 0 | n.a. | n.a | n.a. |
| Ishimori T et al. | 2005 | USA | PET/CT | 1912 | 8 | 8 | 4 | 4 | 0 | 0 | 0 | n.a. | n.a. | n.a. |
| Gutman F et al. | 2005 | France | PET/CT | 1716 | 45 | n.a. | 21 | 3 | 10 | 1 | 7 | 15 ± 11.6 | 12.0±3.7 | 25 |
| van Westreenen HL et al. | 2005 | The Netherlands | PET | 366 | 11 | 11 | 8 | 2 | 6 | 0 | 0 | n.a. | n.a. | n.a. |
| Israel O et al. | 2005 | Israel | PET/CT | 4390 | n.a. | n.a. | 24 | 6 | 9 | 3 | 6 | n.a. | 14.0 ± 10.5 | n.a. |
| Even-Sapir E et al. | 2006 | Israel | PET/CT | 2360 | 33 | 39 | 29 | 13 | 7 | 5 | 4 | n.a | n.a | n.a. |
| Wang G et al. | 2007 | China/Australia | PET/CT | 1727 | n.a. | n.a. | 11 | 1 | 3 | 4 | 3 | n.a. | n.a. | n.a. |
| Hemandas AK et al. | 2008 | UK | PET/CT | 110 | 10 | 10 | 7 | 0 | 7 | 0 | 0 | n.a. | n.a. | n.a. |
| Terauchi T et al. | 2008 | Japan | PET | 2911 | n.a. | 111 | 111 | 7 | 11 | 9 | 84 | 8.31 | n.a. | n.a. |
| Lee ST et al. | 2008 | Australia | PET/CT | 2916 | 85 | 95 | 45 | 12 | 24 | 2 | 7 | n.a. | n.a. | n.a. |
| Tessonnier L et al. | 2008 | France | PET/CT | 4033 | n.a. | n.a. | 44 | 8 | 25 | 4 | 7 | 12.3 ± 5 | 9.8 ± 6.1 | 8.2±2.1 |
| Strobel K et al. | 2009 | Switzerland | PET/CT | 598 | n.a. | 14 | 14 | 5 | 8 | 0 | 1 | n.a. | n.a. | n.a. |
| Lee JC et al. | 2009 | Australia | PET/CT | 1665 | 62 | 70 | 35 | 11 | 12 | 5 | 7 | n.a. | n.a. | n.a. |
| Weston BR et al. | 2010 | USA | PET/CT | 330 | 50 | 52 | 52 | 10 | 25 | 2 | 15 | 17.2* | 14.2 ± 7.2* | n.a. |
| Kei PL et al. | 2010 | USA/Singapore/Hong Kong | PET/CT | 2250 | n.a. | n.a. | 22 | 4 | 13 | 1 | 4 | n.a. | 20.7 ± 11.3* | 12.0* |
| Özkol V et al. | 2010 | Turkey | PET/CT | 2370 | n.a | n.a. | 16 | 3 | 3 | 7 | 3 | n.a. | n.a. | n.a. |
| Luboldt W et al. | 2010 | Germany | PET/CT | 2338 | 50 | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. | n.a. |
| Peng J et al. | 2011 | China | PET/CT | 10978 | 148 | n.a. | 125 | 32 | 23 | 5 | 65 | 9.7* | 8.2* | 6.1* |
| Treglia G et al. | 2012 | Italy | PET/CT | 6000 | 64 | n.a. | 51 | 13 | 19 | 8 | 11 | 9.6 ± 4.7 | 8.5 ± 5.2 | 6.5 ± 3.6 |
| Farquharson AL et al. | 2012 | UK | PET/CT | 555 | 53 | n.a. | 26 | 2 | 17 | 3 | 4 | n.a. | n.a. | n.a. |
| Salazar Andia G et al. | 2012 | Spain | PET/CT | 2220 | n.a. | n.a. | 55 | 13 | 27 | 10 | 5 | n.a. | n.a. | n.a. |
| Oh J-R et al. | 2012 | Republic of Korea | PET/CT | 21317 | n.a. | 296 | 102 | 32 | 43 | 13 | 14 | 13.6 ± 4.9* | 8.4 ± 4.5* | 6.8* |
| Lin M et al. | 2012 | Australia | PET/CT | 649 | n.a. | n.a. | 18 | 3 | 9 | 4 | 2 | 6.0 | 10.4 | 5.8 |
| Yildirim D et al. | 2012 | Turkey | PET/CT | 823 | 28 | 28 | 19 | 6 | 2 | 1 | 10 | n.a | n.a | n.a. |
| Gill RS et al. | 2012 | Canada | PET or PET/CT | 1500 | 21 | 21 | 7 | 2 | 2 | 1 | 2 | 7.4 | n.a. | 4.1 |
| Shim JH et al. | 2012 | South Korea | PET/CT | 239 | 39 | 46 | 46 | 8 | 24 | 14 | 8.9 | 5.5 | n.a. | |
FCIs = focal colorectal incidental uptake; pts = patients; n.a. = not available;
*
significant statistical difference