Fig. 3.

Citrulline enhances ApoAI- and HDL-mediated cholesterol efflux in macrophages. The indicated doses of citrulline (Cit) or control (Cont) were added to the cultures after [³H] cholesterol labeling, which were then incubated in the presence of 10 µg/ml of human apoA-I (A) or 50 µg/ml of HDL (B) for 24 h. Determination of cholesterol efflux from the cells was performed as described in Materials and Methods. The results for 6 samples are presented as the mean ± SEM. *p<0.05 vs Cont.