Figure 1.

mTORC1 is required for reconsolidation of cued fear memory. Reconsolidation of cued fear memory was tested in mice treated with either vehicle or inhibitors of mTORC1 and its effectors. A, Rapamycin-treated mice (n = 6 per treatment) exhibited a significant decrease in freezing behavior during PR-LTM (**p = 0.007). 4EGI-1-treated mice (B, n = 7 per treatment) and S6K1 knock-out (KO) mice (C; n = 6 per genotype) did not exhibit an impairment in the PR-LTM. The timeline of the experiments is depicted above each figure. Horizontal lines represent the tone (CS) presented during reactivation (1 presentation) or PR-LTMs (3 presentations). Transverse dashed lines symbolize the interval between the reactivation and the PR-LTM test. Data are represented as mean ± SEM in all graphs.