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. 2014 Jul 2;34(27):9059–9066. doi: 10.1523/JNEUROSCI.1395-14.2014

Figure 2.

Figure 2.

BLA-induced plasticity in the PFC remained unaltered by the early adolescent MK-801 treatment. a, Timeline of the experimental design and summary of the recording sites (PFC: +3.2 to +2.7 mm from bregma) and stimulating sites (BLA: −3.3 to −3.6 mm from bregma). b, PFC LFP recordings from adult rats that received saline (n = 9) or MK-801 (n = 9) treatment during early adolescence (P35–40). HFS of the BLA resulted in PFC LTP in both saline- and MK-801-treated groups. c, PFC infusion of picrotoxin (50 μm/1 μl; n = 8) failed to affect the BLA-induced LTP in adult naive rats (P60–80). d, Summary of the mean LFP response obtained at 30–40 min post-HFS. **p < 0.005, ***p < 0.0005 vs baseline, paired t test. Insets in b and c are example traces of the BLA-evoked PFC response taken from 5 min pre-HFS (−5) and 35 min post-HFS (+35). Calibration: 4 mV, 20 ms.