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. 2014 Jul 2;34(27):9059–9066. doi: 10.1523/JNEUROSCI.1395-14.2014

Figure 4.

Figure 4.

The normal vHipp-mediated inhibitory control of BLA-dependent plasticity in the PFC is lacking after early adolescent MK-801 treatment. a, Timeline of the experimental design and summary of the recording sites (PFC) and stimulating sites (vHipp and BLA). b, Impact of vHipp HFS before induction of BLA-dependent PFC LTP recorded from adult rats (P65–85) that received saline (n = 7) or MK-801 (n = 7) treatment during early adolescence. Typically, vHipp HFS prevents the expression of BLA-induced LTP in the PFC of saline controls. Such inhibitory control by the vHipp drive is lacking in the MK-801-treated group. c, Summary of the mean PFC response obtained at 30–40 min post-HFS. Two-way ANOVA revealed a main effect of treatment (F(1,24) = 16.1, p < 0.005), a main effect of input stimulation (F(1,24) = 12.9, p < 0.002), and a treatment × input stimulation interaction (F(1,24) = 5.5, p < 0.03; ###p < 0.0005 vs saline, +++p < 0.0005 vs vHipp HFS, LSD post hoc test). d, Example traces of the BLA-evoked PFC response recorded at 5 min pre-vHipp HFS (−5), 35 min post-vHipp HFS (+35), and 40 min post-BLA HFS (+80). Calibration: 4 mV, 20 ms.