Skip to main content
. 2014 Jul 2;34(27):9059–9066. doi: 10.1523/JNEUROSCI.1395-14.2014

Figure 5.

Figure 5.

Impact of MK-801 treatment during adulthood on vHipp-dependent regulation of BLA transmission in the PFC. a, Timeline of the experimental design. Note that another cohort of early adolescent MK-801-treated rats was included to control for the age of the recording period. b, Summary of the recording sites (PFC) and stimulating sites (BLA and vHipp). c, Relative to saline controls (n = 7), the characteristic vHipp-induced depotentiation of the BLA-LTP remained intact in the PFC of adult MK-801-treated rats (n = 6). This was not the case in rats treated in early adolescence as the impaired vHipp-dependent depotentiation of the BLA-LTP resulting from MK-801 exposure (Fig. 3) endures through the P105–125 period (n = 5). d, Summary of the mean PFC response obtained at 30–40 min post-HFS. Two-way ANOVA of the MK-801-treated groups (adult treated, black; adolescent treated, white) revealed a main effect of age of treatment (F(1,18) = 42.1, p < 0.0005), a main effect of input stimulation (F(1,18) = 24.6, p < 0.0005), and an age of treatment × input stimulation interaction (F(1,18) = 28.6, p < 0.0005; ###p < 0.0005 vs adult treated, +++p < 0.0005 vs BLA HFS, LSD post hoc test). e, HFS of the vHipp before induction of BLA LTP in the PFC of adult rats indicate that MK-801 exposure during adulthood did not impair the normal inhibitory control of the vHipp drive (n = 6 per group). This was not the case for the early adolescent MK-801-treated group in which vHipp HFS failed to prevent the expression of BLA-LTP in the PFC, an impairment that endures through P105–125 period (n = 5). f, Summary of the mean PFC response obtained at 30–40 min post-HFS. Two-way ANOVA of the MK-801-treated groups (adult treated, black; adolescent treated, white) revealed a main effect of age of treatment (F(1,18) = 46.8, p < 0.0005), a main effect of input stimulation (F(1,18) = 30.4, p < 0.0005), and an age of treatment × input stimulation interaction (F(1,18) = 31.8, p < 0.0005; ###p < 0.0005 vs adult treated, +++p < 0.005 vs vHipp HFS, LSD post hoc test).