Skip to main content
. 2014 Jul 2;34(27):9059–9066. doi: 10.1523/JNEUROSCI.1395-14.2014

Figure 7.

Figure 7.

Reversal effect of the GABAAα1-positive allosteric modulator indiplon on PFC plasticity. a, Timeline of the experimental design and summary of the recording sites (PFC) and stimulating sites (BLA and vHipp). b, Local PFC infusion of indiplon before vHipp HFS (n = 7) was sufficient to restore the normal vHipp depotentiation of BLA-dependent LTP in MK-801-treated rats (MK). This reversal effect was not observed when aCSF alone was delivered into the PFC (n = 7). c, Analysis of the mean PFC response obtained at 30–40 min post-HFS revealed a main effect of infusion (F(1,24) = 11.3, p < 0.005), a main effect of input stimulation (F(1,24) = 4.5, p < 0.05), and an infusion × input stimulation interaction (F(1,24) = 5.8, p < 0.05; ###p < 0.0005 vs aCSF, ++p < 0.005 vs BLA HFS, LSD post hoc test). d, Example traces of the BLA-evoked PFC response recorded at 5 min pre-BLA HFS (−5), 35 min post-BLA HFS (+35), and 40 min post-vHipp HFS (+80). Calibration: 4 mV, 20 ms.