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. 2014 Jul 2;34(27):9059–9066. doi: 10.1523/JNEUROSCI.1395-14.2014

Figure 8.

Figure 8.

Local prefrontal facilitation of GABAAα1 function restores the normal vHipp inhibitory control of BLA transmission. a, Timeline of the experimental design and summary of the recording sites (PFC) and stimulating sites (BLA and vHipp). b, Local PFC infusion of indiplon effectively rescued the vHipp-dependent blockade of BLA induction of LTP in MK-801-treated rats (MK). Note that the effectiveness of indiplon in restoring the action of vHipp HFS on the expression of BLA-LTP occurred only when drug infusion was delivered before vHipp HFS (n = 7). Indiplon infusion before BLA HFS (n = 6) failed to reinstate this inhibition. c, Summary of the mean PFC response obtained at 30–40 min post-HFS. Two-way ANOVA revealed a main effect of infusion (F(1,22) = 43.4, p < 0.0005), a main effect of input stimulation (F(1,22) = 19.99, p < 0.0005), and an infusion × input stimulation interaction (F(1,22) = 20.4, p < 0.0005; ###p < 0.0005 vs pre-BLA, +++p < 0.0005 vs vHipp HFS, LSD post hoc test). d, Example traces of the BLA-evoked PFC response recorded at 5 min pre-vHipp HFS (−5), 35 min post-vHipp HFS (+35), and 40 min post-BLA HFS (+80). Calibration: 4 mV, 20 ms.