Table 1.

Summary of the effect of MPTP intoxication and of subsequent l-dopa treatment on sleep parameters^a

Treatment	TST min	Sleep efficiency	Night TST (100%)			WASO (%)	Wake (%)	Sleep onset to REM (min)	Daytime sleep (%)
			Stage 1–2	SWS	REM
Control mean	595.8	83.0	54.5	23.8	22.0	14.2	17.0	49.6	1.6
SEM	7.0	2.0	4.0	3.0	1.0	2.0	1.5	10.0	1.0
MPTP mean	410.5***	57.1***	67.4**	12.5***	17.3***	40.0***	42.9***	101.5*	12.8***
SEM	25.0	3.6	3.2	2.8	1.7	4.9	3.8	10.1	2.7
l-Dopa mean	452.9*	63.1*	64.9	13.2	19.1*	32.4	37.0*	98.8	5.8**
SEM	18.1	2.6	4.1	3.4	1.3	3.7	2.6	10.8	1.6
PPN 3w mean	489.4	69.3	66.2	14.2	18.2	35.8	30.7	127.0	4.7
SEM	36	6.5	4.4	2.2	3.5	14.9	6.5	15.1	1.6

^aMean values of sleep parameters were calculated in 4 macaques in the control state, after MPTP intoxication, and then after l-dopa treatment, in 3 macaques 3 weeks (3w) after a unilateral PPN lesion and in one of these macaques after a second PPN lesion in the other hemisphere. MPTP values were compared with control values, and l-dopa values with MPTP values. Level of significance was given only in the case of statistical significance for each individual.

*p < 0.05;

**p < 0.01;

***p < 0.001: Kruskal–Wallis test followed by Mann–Whitney U test in the event of statistically significant differences.