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. Author manuscript; available in PMC: 2014 Jul 2.
Published in final edited form as: Cancer Res. 2012 Sep 24;72(22):5856–5866. doi: 10.1158/0008-5472.CAN-12-1635

Figure 7. Pi3k/mTOR blockade abrogates basal but not luminal MEC overgrowth across a range of Ras activation levels and inhibitor doses.

Figure 7

BasalRAS/GFP and luminalRAS/GFP organoids were cultured under the indicated treatment conditions for 6 d. 2D image morphometry was used to determine mean organoid area. (A) LY effects on organoid size across varied Dox doses. When administered, the LY dose was held constant at 10 μM. (B) Inhibitor effects on organoid size across varied drug doses. When administered, the Dox dose was held constant at 1000 ng/ml. Mean values reflect analysis of 18 to 34 organoids for each genotype and treatment condition. Error bars denote SEM.