Figure 1.

Each site will install the Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS) Sidecar, for identifying and reviewing cohorts and the mySCILHS suite to: (a) manage linkage of contact data to the de-identified Patient Cohort list produced by the multisite Shared Health Research Information Network (SHRINE) query; (b) administer and store consent documents; (c) outreach to patients through web-based survey and telephony; and (d) promote ongoing patient engagement through outgoing messaging, including (in the future) return of research results to patients. The web-based survey will be administered using REDCap and Indivo technologies, and will be accessible either by patients at home, or at the point of care, through tablet/kiosk-based interaction. Once completed, patient-reported data will have subject identifiers encoded; its standardized survey metadata will then be loaded into the corresponding SCILHS sidecar (i2b2 node), enabling semantic data linkage with electronic health record data via SHRINE/i2b2, while preserving subject confidentiality. These software platforms will be provided to sites as self-contained, pre-configured virtual machines, enabling rapid dissemination of these technologies while minimizing administrative and software development overhead at each site.