Table 2. Body weight, adiposity, tissue weights and systemic lipid abundance.

	Chow	Lard HFD	10% Fish oil	50% Fish Oil	90% Fish Oil	WY-14,643
Initial body weight (g)	28.7 ± 0.2	27.3 ± 0.4	27.3 ± 0.7	27.0 ± 0.5	27.1 ± 0.5	27.5 ± 0.4
End point body weight (g)	29.5 ± 0.3	34.0 ± 0.7a	32.1 ± 1.3	31.0 ± 1.1	30.5 ± 0.8	32.4 ± 0.6
End point adiposity (% body fat)	12.5 ± 0.4	29.4 ± 1.3c	24.2 ± 2.0c	21.7 ± 1.2c,e	16.0 ± 0.9f,*,‡	26.4 ± 1.2c
Epididymal fat pad (%body weight)	1.6 ± 0.2	4.3 ± 0.2c	3.2 ± 0.3c,d	3.0 ± 0.2c,e	2.3 ± 0.2f,*	3.1 ± 0.2c,d
Inguinal fat pad (%body weight)	1.0 ± 0.03	2.4 ± 0.2c	2.0 ± 0.2c	2.0 ± 0.2c	1.3 ± 0.09f,*	1.8 ± 0.06b
Liver weight (%body weight)	4.6 ± 0.2	3.5 ± 0.1c	3.7 ± 0.2c	4.5 ± 0.2f	5.3 ± 0.1a,f	5.8 ± 0.1c,f
BAT weight (%body weight)	0.3 ± 0.02	0.3 ± 0.01	0.3 ± 0.03	0.4 ± 0.02	0.3 ± 0.02	0.4 ± 0.02
Serum NEFA (mM)	0.7 ± 0.06	0.8 ± 0.04	0.8 ± 0.06	0.6 ± 0.04d	0.6 ± 0.02e	0.5 ± 0.01b,f
Serum TAG (mM)	1.1 ± 0.1	1.4 ± 0.1	1.0 ± 0.07e	0.7 ± 0.07b,f	0.5 ± 0.03c,f	0.5 ± 0.03c,f

Mice were maintained on chow or high-fat diets containing different proportions of FO or WY-14,643 for 8 weeks. Adiposity was determined by DEXA. Tissue weights and serum samples were obtained at the end of feeding period when the animals were culled. Serum NEFA and TAG were measured enzymatically. Data are the means ± SEMs of 8–10 animals per group.

^a,b,cp < 0.05, 0.01, 0.001 vs chow;

^d,e,fp < 0.05, 0.01, 0.001 vs lard;

*p < 0.05 compared to 50%FO;

^‡p < 0.001 compared to 10%FO.