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. Author manuscript; available in PMC: 2014 Jul 2.
Published in final edited form as: Cancer Discov. 2013 Jun 2;3(6):658–673. doi: 10.1158/2159-8290.CD-12-0558

Figure 1. Whole exome analysis reveals increased MET copy number in CRC samples from patients who developed resistance to anti-EGFR treatment.

Figure 1

A–C left side. Whole exome gene copy number analysis of colorectal tumor samples from three patients taken before (in blue) and after (in red) therapy with the EGFR targeted monoclonal antibodies panitumumab (Pmab, patients 1 and 2) or cetuximab (Cmab, patient 3). Individual chromosomes are indicated on the x-axis. The lines indicate the sequencing depth as copy number values relative to a diploid exome (y-axis) over windows of 500,000 base pairs. A–C right side MET amplification was confirmed in the paired tumor samples by quantitative PCR gene copy number analysis. GCN= Gene Copy Number; MAD1L1: reference gene on Chr.7; NGS= next generation sequencing.