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Strategy for controlling the expression of siRNA with TAT-NLS-Cre. In the absence of TAT-NLS-Cre, transcription stops just after the sense sequence, yielding incomplete siRNAs. Thus, RNAi cannot occur. In the presence of TAT-NLS-Cre, recombination occurs and the region between loxP sites is excised. As a result, complete stem-type siRNAs are formed and induce silencing of the target gene.
