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. 2004 Mar 19;4:3. doi: 10.1186/1475-2867-4-3

Table 1.

Different cancer cell lines are represented for their mean % survival in presence of different drugs as shown in Figure 2A.

Drug VP 16 (Dose) Mean % survival with VP 16(n = 5) Drug with PC3 cells Endlabelling Fluorescence (A.U.)
LNCaP PC3 DU145 Control Taxotere 2

2 μg/ml 85 96 75 10 nM 10
5 μg/ml 80 84 70 50 nM 10
10 μg/ml 85 82 65 Campothecin
20 μg/ml 80 72 55 200 nM 135

Notice the most pronounced response of DU 145 followed by PC3 and LNCaP cell lines against VP 16 (20 μg/ml). Dynamic range of the mean endlabelling fluorescence intensity was normalized to arbitrary control value of 1.0 non-linear scale (n = 5). The combination of taxotere on PC3 was apparently saturated at 10 nM for 24 hours at about 10% of the campothecin dose, a near maximal response.