Table 5.
Geometric mean phthalate metabolite concentrations in pregnant women within TIDES cohort (ng/mL) (n = 656).
| Parent | Metabolite | LOD (CDC) | LOD (UW) a | % >LOD | USG-Adjusted Geometric Mean (95% CI) b | Unadjusted Geometric Mean (95% CI) | NHANES 2011–2012 c |
|---|---|---|---|---|---|---|---|
| DEP | MEP | 0.6 | 1 | 99.1 | 35.63 (32.09–39.56) | 27.85 (24.61–31.50) | 33.36 (23.85–46.64) |
| DiBP | MiBP | 0.2 | 0.2 | 97.0 | 5.08 (4.76–5.42) | 3.97 (3.58–4.40) | 5.76 (4.60–7.23) |
| DnBP | MnBP | 0.4 | 1 or 2 | 92.1 | 8.23 (7.69–8.82) | 6.43 (5.81–7.13) | 6.83 (5.06–9.22) |
| BzBP | MBzP | 0.3 | 1 | 86.9 | 4.28 (3.94–4.64) | 3.34 (3.00–3.73) | 4.20 (3.39–5.20) |
| DEHP | MEHP | 0.5 | 1 | 65.7 | 2.54 (2.37–2.73) | 1.99 (1.81–2.18) | 1.61 (1.38–1.89) |
| MEHHP | 0.2 | 0.2 or 1 | 96.8 | 7.68 (7.16–8.25) | 6.01 (5.43–6.64) | 7.43 (6.34–8.71) | |
| MEOHP | 0.2 | 1 | 97.1 | 5.56 (5.19–5.95) | 4.34 (3.94–4.79) | 5.12 (4.38–5.98) | |
| MECPP | 0.2 | 0.2 or 1 | 97.1 | 10.05 (9.41–10.72) | 7.85 (7.14–8.64) | 12.09 (10.45–13.98) | |
| ∑ DEHP Metabolites d | 90.96 (85.35–96.95) | 71.09 (64.73–78.08) | N/A |
Notes: a Samples were analyzed in 2 batches. Two LODs reported due to differences in instrument sensitivity and/or level of background; b Adjusted for urine specific gravity; c Female population of reproductive age (20–40 years) values calculated from Centers for Disease Control and Prevention (CDC). National Center for Health Statistics (NCHS). National Health and Nutrition Examination Survey Data. US Department of Health and Human Services, Centers for Disease Control and Prevention, 2011–2012 [25]; unadjusted weighted geometric means.; d ∑ DEHP Metabolites is the sum of each metabolite divided by its molecular weight (MEHP, MEHHP, MEOHP, MECPP); * 1,000 reported in nnmol/L;