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Immunolocalization of insulin and C-peptide. β cells from either C57BL/6J (a) or Mody (b) mice were double immunolabeled for insulin (large gold particles) and C-peptide (small gold particles). Although insulin and C-peptide signals are profoundly decreased in the secretory granules in Mody mice compared with the control strain (arrows), a significant amount of C-peptide immunoreactivity exists in the ER (arrowheads) in Mody mice. Bar, 0.25 μm.
