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Left atrial pathology at postnatal day 6 in α-MHC403/403 mice. (a) Cut section stained with Von Kossa's reagent shows necrosis and calcification of myocardium in the LA appendage. ×80. (b) Echocardiographic findings in an α-MHC403/403 mouse with LV dilation and contractile dysfunction. Two-dimensional echocardiographic images show dense echogenicity consistent with thrombus formation in a dilated LA. Scale bar, 1 mm.
