Skip to main content
. Author manuscript; available in PMC: 2014 Jul 2.
Published in final edited form as: Leukemia. 2010 Nov 12;25(2):281–289. doi: 10.1038/leu.2010.263

Figure 3. ROS in cells transformed by tyrosine kinase oncogenes.

Figure 3

Intracellular ROS levels were measured by DCF-DA (A, B, D) or MitoSox (C) staining in tyrosine kinase transformed cells or in response to targeted approaches. A. BaF3 cells expressing either BCR-ABL, JAK2V617F or FLT3ITD were compared to the parental cell line (left panel). B-D. KU812 (BCR-ABL), HEL (JAK2V617F) and Molm13 (FLT3ITD) cells were compared to kinase inhibitor treated cells (18h), as indicated (B-C) or control cells were compared to cells with NOX2, NOX4 and p22phox knockdown (D). (n=3, *p<0.05).