Figure 1. Intratumoral dendritic cell vaccination augments the anti-tumor effects of chemoradiation.
Mice bearing 7-day subcutaneous SCCVII tumors (2.5 × 105 cells) were treated with 2 days of systemic cisplatin (4 mg/kg) and 5-fluorouracil (50 mg/kg) and 5 days of fractionated radiation to the flank tumor site (3 Gy/day; 15 Gy total). Mice were given three weekly intratumoral injections of dendritic cells (1 × 106/injection) beginning on the first day of chemoradiation. The number of long-term surviving mice with complete tumor regression are indicated. (*) p < 0.05 compared to HBSS.