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. Author manuscript; available in PMC: 2014 Jul 2.
Published in final edited form as: Nat Cell Biol. 2013 Mar 17;15(4):373–384. doi: 10.1038/ncb2702

Figure 5.

Figure 5

Kdm2b and PRC1 interact and co-occupy genomic loci (a) A Venn diagram shows the numbers of Ring1b-, Ezh2- and Kdm2b-binding promoters identified by ChIP-seq and their relationship. Co-occupied promoters are indicated by the overlapped areas in the diagram. The numbers of binding sites are indicated in the corresponding area. (b) Bottom, examples of Kdm2b-, Ring1b- and Ezh2-binding peaks across the Hoxa and Hoxd clusters in mESCs. The y axis represents the number of reads in each 10 million total reads. Top, schematic representation of the mouse Hoxa and Hoxd clusters, with the genes and associated CGIs indicated. (c) Co-immunoprecipitation and western blot analysis showing the proteins co-immunoprecipitated with Kdm2b. Full scans of blots are shown in Supplementary Fig. S8c. (d) Co-immunoprecipitation and western blot analysis showing the proteins co-immunoprecipitated with Ring1b. Full scans of blots are shown in Supplementary Fig. S8d.