(A) 4T1-, 66C4-, and nontumor- (NT) bearing mice were assayed at 0, 14, and 28 days post 4T1 tumor inoculation for total adipose tissue content via TD-NMR. (n=4–5 per group; * Tukey’s One way-ANOVA p <0.001). (B) Oxygen consumption (VO2) per total lean tumor free body weight in 4T1- and 66C4- was measured at 0, 14, and 28 days post 4T1 tumor inoculation. Values represent mean ± SD (n=4–5 per group; * Student’s t-test p =0.004)