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. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: J Immunol. 2014 May 14;192(12):6111–6119. doi: 10.4049/jimmunol.1302895

Figure 4. Changes in adiposity, oxygen consumption, and acute phase reactants also occur in other tumor models of cachexia following expansion of Gr-1+CD11b+ cells in the spleen and bone marrow.

Figure 4

CT26 and LLC was inoculated into naïve mice and followed for 21 days. Spleen and bone marrow (A and B) were harvested from tumor bearing animals at 7 day intervals and plotted against tumor free body weight (n=5/group). Total host adipose tissue content (C and D) and oxygen consumption (E and F) were measured at 7 day intervals as well. Values represent mean ± SD (n=5/group; * One way ANOVA on ranks p<0.001; ** Kruskall-Wallis One way ANOVA on ranks p=0.002; *** ANOVA on ranks p=0.009). Finally, serum from tumor bearing host was assayed via ELISA for the presence of serum amyloid A (SAA) and Haptoglobin (G) Values represent mean concentration in ng/mL and are ± SD (n=5/group; * One way ANOVA on ranks p<0.05; **Kruskall-Wallis One way ANOVA on ranks p<0.001).