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. 1999 Jan 15;103(2):219–227. doi: 10.1172/JCI5006

Figure 3.

Figure 3

Influence of purified HDL and LDL or of their PL extracts on inactivation of FVa by APC and protein S. (a) HDL (squares) or LDL (circles) were incubated with FVa (20 pM) for 30 min with 350 pM APC alone (open symbols), 350 pM APC and 14.5 nM protein S (solid symbols), or control buffer (HDL, solid triangles; LDL, open triangles). Residual FVa was measured using prothrombinase assays. FVa activity without HDL or LDL was defined as 100% activity. (b) PL extracts from HDL (squares) or LDL (circles) were tested for their ability to enhance FVa inactivation using the same reagents and conditions as in a. Symbols represent the same variables (APC alone, APC plus protein S, or control buffer) as in a. Concentrations of LDL and HDL or their PL extracts are given based on content of choline-containing PL.