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Chromosomal translocation chemical library screens identified SD70 as a translocation inhibitor. (A) RT-qPCR analysis of fusion genes TMPRSS2:ERG and TMPRSS2:ETV1 in LNCaP cells pretreated with compounds as indicated for 2 h followed by DHT (100 nM) and irradiation (50 Gy) for 24 h. (B) RT-qPCR analysis of fusion genes TMPRSS2:ERG and TMPRSS2:ETV1 in LNCaP cells treated with DHT (100 nM) and irradiation (50 Gy) for 24 h in the presence of validated siRNAs as indicated.
