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(a) Pedigree of the Swiss congenital afibrinogenemia family and haplotypes of the region surrounding the fibrinogen locus. The markers (from top to bottom) and genetic distances were: D4S1625 – (13%) – D4S2962 – (2%) – FGAi3 – (2%) – D4S2934 – (2%) – D4S1629. The FGA deletion (shown as Δ) is associated with three different haplotypes. (b) PAGE analysis of the tetranucleotide repeat marker FGAi3, which is homozygously deleted in individuals 6–9. FGA, fibrinogen alpha-chain gene.
