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Functional assays of platelets in vitro show that the β3-null platelets do not aggregate (a), have reduced clot retraction (b), and greatly reduced fibrinogen uptake (c). A GT is a platelet lysate from an Arab patient with Glanzmann thrombasthenia, who has a defect in GPIIb and I-J GT is a platelet lysate from an Iraqi-Jewish GT patient with a defect in β3 (GPIIIa).
