Table 2.
Quantitative IR820 organ content 24 hours after i.v. injection of IR820-PGMD NPs, IR820 or DOX-IR820-PGMD NPs.
24h organ and plasma IR820 dye content (n=3) | Liver (μg/g) | Lungs (μg/g) | Intestines (μg/g) | Kidneys (μg/g) | Plasma (μg/mL) |
---|---|---|---|---|---|
IR820-PGMD NPs | 0.21±0.09 | 0.23±0.07 | 0.07±0.02 | 0.25±0.09 | *0.18±0.04 |
IR820 | 0.21±0.11 | 0.28±0.03 | 0.05±0.006 | 0.41±0.11 | 0.10±0.003 |
DOX-IR820-PGMD NPs | 0.08±0.01 | 0.26±0.08 | 0.05±0.02 | *0.21±0.04 | *0.26±0.06 |
Values represent average±SD.
P<0.05, significant difference between free IR820 and NP dye content in kidneys and plasma.