Table 2.
The Odds for Both the Presence and Increasing Severity of Venous Disease for Different Adipokines
| PRESENCE OF VENOUS DISEASE | INCREASING SEVERITY OF VENOUS DISEASE | |||||
|---|---|---|---|---|---|---|
| Adipocytokine (tertile cutpoints) | Odds Ratios (95% CI) | Odds Ratios (95% CI) | Odds Ratios (95% CI) | Odds Ratios (95% CI) | ||
| Resistin (11.4, 17.0 ng/ml) | Tertile 2 vs 1 | Tertile 3 vs 1 | 1-SD Increment | Tertile 2 vs 1 | Tertile 3 vs 1 | 1-SD Increment |
| Model 1 | 1.7 (1.2–2.6) | 1.9 (1.3–2.9) | 1.15 (0.98–1.34) | 1.9 (1.3–2.7) | 1.8 (1.3–2.6) | 1.16 (1.01–1.33) |
| Model 2 | 1.7 (1.1–2.5) | 1.9 (1.3–2.8) | 1.10 (0.93–1.29) | 1.9 (1.3–2.8) | 1.7 (1.2–2.5) | 1.11 (0.96–1.28) |
| Adiponectin (17.8, 31.4 ug/ml) | ||||||
| Model 1 | 1.2 (0.8–1.7) | 1.0 (0.7–1.6) | 1.03 (0.87–1.22) | 1.1 (0.8–1.6) | 1.0 (0.7–1.5) | 1.00 (0.85–1.17) |
| Model 2 | 1.3 (0.9–1.9) | 1.3 (0.9–2.1) | 1.15 (0.96–1.37) | 1.2 (0.8–1.8) | 1.4 (0.9–2.1) | 1.12 (0.95–1.32) |
| Leptin (5.1, 13.9 ng/ml) | ||||||
| Model 1 | 1.9 (1.3–2.9) | 2.6 (1.7–4.0) | 1.35 (1.12–1.64) | 2.0 (1.4–3.0) | 3.1 (2.0–4.6) | 1.43 (1.22–1.66) |
| Model 2 | 1.6 (1.1–2.5) | 1.6 (0.9–2.7) | 1.06 (0.86–1.31) | 1.7 (1.1–2.6) | 1.7 (1.1–2.8) | 1.14 (0.96–1.37) |
| Tumor Necrosis Factor-α (2.11, 3.27 pg/ml) | ||||||
| Model 1 | 1.5 (1.0–2.3) | 1.5 (1.0–2.3) | 1.17 (0.98–1.40) | 1.7 (1.2–2.4) | 2.0 (1.4–3.0) | 1.39 (1.19–1.63) |
| Model 2 | 1.4 (0.9–2.1) | 1.3 (0.8–1.9) | 1.09 (0.92–1.30) | 1.4 (1.0–2.1) | 1.7 (1.2–2.5) | 1.28 (1.10–1.49) |
| Interleukin-6 (0.93, 1.74 pg/ml) | ||||||
| Model 1 | 1.5 (1.0–2.2) | 2.5 (1.6–3.8) | 1.24 (1.04–1.47) | 1.5 (1.0–2.2) | 2.7 (1.8–4.0) | 1.39 (1.20–1.61) |
| Model 2 | 1.3 (0.9–2.0) | 1.8 (1.1–2.8) | 1.09 (0.91–1.30) | 1.3 (0.9–2.0) | 1.8 (1.2–2.9) | 1.21 (1.03–1.41) |
Model 1: Age (continuous), sex, race; Model 2: Model 1 + body mass index (continuous)
Adipokine Tertile Sample sizes:
Resistin: Tertile 1 = 189, Tertile 2 = 240, Tertile 3 = 256
Adiponectin: T1 = 215, T2 = 230, T3 = 240
Leptin: T1 = 182, T2 = 238, T3 = 265
Tumor Necrosis Factor - alpha: T1 = 202, T2 = 240, T3 = 243
Interleukin-6: T1 = 175, T2 = 195, T3 = 254