Figure 3.

Palladium-mediated conversion assay in cell-free biocompatible conditions. (a) SEM image of Pd⁰-resins. Scale bar = 150 μm. (b) Pd⁰-mediated carbamate cleavage of compounds 5a,p,b. (c) HPLC chromatogram of unmodified gemcitabine (1). (d–f) HPLC chromatograms (UV detector 280 nm) of 100 μM PBS solutions of compounds 5a (left panel), 5p (central panel), and 5b (right panel) treated with Pd⁰-resins at 37 °C for 0 h (top), 6 h (central), and 24 h (bottom). (g) Proposed mechanism for the Pd⁰-catalyzed cleavage of O/N-propargyl groups in water.