Table 4.

Univariate and multivariate Cox analysis predicting fatal and nonfatal CV events (a composite of 129 fatal and nonfatal events)

Parameters	Univariate Cox			Multivariate Cox
	Hazard Ratio	95% Confidence Interval	P Value	Hazard Ratio	95% Confidence Interval	P Value
FMD (%)	0.61	0.53 to 0.71	<0.001a
IL-10 tertiles, pg/ml	1.04	1.03 to 1.05	<0.001a	1.62	1.09 to 2.40	0.02a
IL-6 tertiles, pg/ml	1.29	1.04 to 1.60	0.02a	1.35	1.04 to 1.74	0.02a
IL-6/IL-10 ratio	0.09	0.04 to 0.22	<0.001a	0.25	0.09 to 0.71	<0.01a
PTX-3, ng/ml	1.03	1.02 to 1.04	<0.001a	1.02	1.01 to 1.03	0.004a
hsCRP, mg/L	1.04	1.02 to 1.06	0.001a
Serum albumin, g/dl	0.56	0.33 to 0.97	0.04a
eGFR, ml/min	0.99	0.98 to 0.99	<0.001a
Diabetes (yes/no)	5.11	3.62 to 7.23	<0.001a	4.41	3.08 to 6.33	<0.001a
Hypertension (yes/no)	2.15	1.45 to 3.19	<0.001a
Smoking (yes/no)	1.82	1.28 to 2.59	0.001a
History of CV disease	1.01	0.84 to 1.23	0.90
24-h proteinuria, mg/d	1.00	1.00 to 1.01	0.63
Systolic BP, mmHg	1.03	1.01 to 1.04	<0.001a
LDL cholesterol, mg/dl	1.00	0.99 to 1.01	0.79
HOMA-IR	1.36	1.19 to 1.55	<0.001a
Calcium, mg/dl	0.86	0.63 to 1.17	0.35
Phosphate, mg/dl	1.14	1.03 to 1.28	0.02a
iPTH, pg/ml	1.01	1.00 to 1.01	<0.001a
Age, yr	1.00	0.99 to 1.01	0.90
Sex (men/women)	1.31	0.91 to 1.87	0.14

iPTH, intact parathyroid hormone.

^aStatistically significant (P<0.05).