Table 4.
Parameters | Univariate Cox | Multivariate Cox | ||||
---|---|---|---|---|---|---|
Hazard Ratio | 95% Confidence Interval | P Value | Hazard Ratio | 95% Confidence Interval | P Value | |
FMD (%) | 0.61 | 0.53 to 0.71 | <0.001a | |||
IL-10 tertiles, pg/ml | 1.04 | 1.03 to 1.05 | <0.001a | 1.62 | 1.09 to 2.40 | 0.02a |
IL-6 tertiles, pg/ml | 1.29 | 1.04 to 1.60 | 0.02a | 1.35 | 1.04 to 1.74 | 0.02a |
IL-6/IL-10 ratio | 0.09 | 0.04 to 0.22 | <0.001a | 0.25 | 0.09 to 0.71 | <0.01a |
PTX-3, ng/ml | 1.03 | 1.02 to 1.04 | <0.001a | 1.02 | 1.01 to 1.03 | 0.004a |
hsCRP, mg/L | 1.04 | 1.02 to 1.06 | 0.001a | |||
Serum albumin, g/dl | 0.56 | 0.33 to 0.97 | 0.04a | |||
eGFR, ml/min | 0.99 | 0.98 to 0.99 | <0.001a | |||
Diabetes (yes/no) | 5.11 | 3.62 to 7.23 | <0.001a | 4.41 | 3.08 to 6.33 | <0.001a |
Hypertension (yes/no) | 2.15 | 1.45 to 3.19 | <0.001a | |||
Smoking (yes/no) | 1.82 | 1.28 to 2.59 | 0.001a | |||
History of CV disease | 1.01 | 0.84 to 1.23 | 0.90 | |||
24-h proteinuria, mg/d | 1.00 | 1.00 to 1.01 | 0.63 | |||
Systolic BP, mmHg | 1.03 | 1.01 to 1.04 | <0.001a | |||
LDL cholesterol, mg/dl | 1.00 | 0.99 to 1.01 | 0.79 | |||
HOMA-IR | 1.36 | 1.19 to 1.55 | <0.001a | |||
Calcium, mg/dl | 0.86 | 0.63 to 1.17 | 0.35 | |||
Phosphate, mg/dl | 1.14 | 1.03 to 1.28 | 0.02a | |||
iPTH, pg/ml | 1.01 | 1.00 to 1.01 | <0.001a | |||
Age, yr | 1.00 | 0.99 to 1.01 | 0.90 | |||
Sex (men/women) | 1.31 | 0.91 to 1.87 | 0.14 |
iPTH, intact parathyroid hormone.
Statistically significant (P<0.05).