Table 1.
Patients with CKD on dialysis clinical and serum biochemical characteristics at baseline and 1 year
| Variables and Serum Biochemical Values | At Baselinea | Normal Range | At 1 Yeara | Differencea | P Value |
|---|---|---|---|---|---|
| Variables | |||||
| No. of patients | 81 | ||||
| BMI, mean±SD | 31.3±7.8 | ||||
| Dialysis vintage, median mo (range) | 41 (3–241) | ||||
| Patients with diabetes, % | 46.1 | ||||
| Smoked within 2 yr, % | 28.6 | ||||
| Tx with active 1,25 OH D, % | 56.8 | 64.2 | 7.4 | 0.42 | |
| Tx with cinacalcet, % | 23.8 | 29.5 | +5.7 | 0.28 | |
| Tx with phosphate binders, % | 91.3 | 85.1 | −6.2 | 0.20 | |
| Calcium containing, % | 40.7 | 37.0 | −10.0 | 0.75 | |
| Serum biochemical values | |||||
| Calcium, mg/dl | 8.8±0.8 | 8.4–10.2 | 9.0±0.9 | 0.2±0.9 | 0.09 |
| Phosphorus, mg/dl | 5.8±1.6 | 2.6–4.5 | 5.5±1.5 | −0.2±1.8 | 0.50 |
| Intact PTH, pg/ml | 342 (176–522) | 14–66 | 315 (174–491) | 14 (−162–166) | 0.94 |
| BSAP, unit/L | 63.0±37.8 | 15–75 | 58.6±44.0 | −2.5±51.4 | 0.54 |
| FGF23, RU/ml | 5056 (1659–12,998) | <180 | 9701 (2270–15,945) | 1454 (−246–7905) | <0.001b |
| TRAP-5b, unit/L | 7.50±4.34 | 1.2–6.7 | 7.64±3.74 | 0.60±3.09 | 0.11 |
| P1NP, ng/ml | 47.3±25.0 | 32.8–57.4 | 19.6±19.5 | −28.1±31.0 | <0.001b |
| Sclerostin, pg/ml | 1282±696 | 130–1160 | 1376±640 | 182±384 | <0.001b |
| DKK-1, pmol/L | 30.5±28.4 | 28–256 | 41.9±23.6 | 14.9±28.8 | <0.001b |
BMI, body mass index; Tx, treatment; 1,25 OH D, 1,25-dihydroxyvitamin D; PTH, parathyroid hormone; BSAP, bone-specific alkaline phosphatase; FGF23, fibroblast growth factor 23; TRAP-5b, tartrate-resistant acid phosphatase-5b; P1NP, procollagen type 1 N-terminal propeptide; DKK-1, Dickkopf-1.
a
Mean±SD or median (interquartile range) or percentage.
b
P<0.001.