Table 3.
Independent association of conventional mineral markers with all-cause mortality and CV events in large prospective nondialysis-dependent CKD cohort studies
| Study | End Point | Phosphate | PTH | 25(OH)D | 1,25(OH)2D | FEP |
|---|---|---|---|---|---|---|
| CRIC (4,6) | All-cause mortality | NR | No | NA | NA | No |
| CRIC (4,6) | Atherosclerotic events | Yes; HR, 1.1 (95% CI, 1.0 to 1.2) per 0.5 mg/dl | No | NA | NA | No |
| CRIC (4,6) | Heart failure events | Yes; HR, 1.1 (95% CI, 1.0 to 1.2) per 0.5 mg/dl | No | NA | NA | NA |
| HOST (5,56) | All-cause mortality | No | No | No | No | NA |
| HOST (5,56) | CV events | Yes; HR, 1.2 (95% CI, 1.1 to 1.3) per mg/dl | No | No | Not independent of FGF23 | NA |
| AASK (46) | All-cause mortality and initiation of RRT (composite) | Only at high levels>3.5 mg/dl; HR, 1.3 (95% CI, 1.2 to 1.5) per 0.5 mg/dl; not significant in tertile analysis | Only at high levels>39 pg/ml; HR, 1.3 (95% CI, 1.1 to 1.5) per doubling; not significant in tertile analysis | No | NA | NA |
| OVIDS-CKD (42) | CV events predialysis | NR | No | No; predictive of death but not independently of hemoglobin | No | NA |
| Wolf et al. (44) | All-cause mortality and allograft loss (composite) | Yes; HR, 1.2 (95% CI, 1.1 to 1.4) per 1 SD; not significant in tertile analysis or patients with eGFR=30–90 ml/min per 1.73 m2 | No | NA | NA | NA |
| Baia et al. (45) | CV mortality | No | No | No | No | No |
CV, cardiovascular; PTH, parathyroid hormone; 25(OH)D, 25 hydroxyvitamin D; 1,25(OH)2D, 1,25 dihydroxyvitamin D; FEP, fractional excretion of phosphate; NR, not reported; NA, not assessed; HR, hazard ratio.