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. Author manuscript; available in PMC: 2014 Jul 2.
Published in final edited form as: Immunol Endocr Metab Agents Med Chem. 2011;11(4):255–261. doi: 10.2174/1871522211108040255

Figure 1.

Figure 1

GPER/GPR30-dependent regulation of vascular tone. In carotid arteries of wild-type mice (GPER +/+), the selective GPER/GPR30-agonist G-1 causes time-dependent acute dilation, which is absent in GPER/GPR30-knockout animals (GPER −/−, A). In murine carotid (B) and human internal mammary arteries (C), the dilator effect of G-1 is even stronger than that of 17β-estradiol (E2). Injection of G-1 at increasing doses (4.12 ng/kg, 41.2 ng/kg, 412 ng/kg, and 20.6 μg/kg) acutely reduces mean arterial blood pressure (MAP, calculated as 1/3 Max + 2/3 Min, where Max is the systolic pressure and Min the diastolic pressure) in normotensive male rats. For comparison, the response to achetylcholine (ACh, 30 ng/kg) is shown (D). Reproduced from Haas, E., Bhattacharya, I., Brailoiu, E., Damjanovic, M., Brailoiu, G.C., Gao, X., Mueller-Guerre, L., Marjon, N.A., Gut, A., Minotti, R., Meyer, M.R., Amann, K., Ammann, E., Perez-Dominguez, A., Genoni, M., Clegg, D.J., Dun, N.J., Resta, T.C., Prossnitz, E.R., Barton, M., Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity, Circ Res, 104(3), 288-291, ©2009 by the American Heart Association. Figure reproduced with the permission of the publisher.