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. 1999 Feb 1;103(3):383–391. doi: 10.1172/JCI4901

Figure 5.

Figure 5

CCK-AR–/– mice have normal pancreatic histology and blood glucose levels (a) Normal histology of exocrine and endocrine pancreatic tissue from CCK-AR–/– mice. Non-β islet cells were immunostained; sections were counterstained with hematoxylin and eosin. Both the islet and acinar gland morphology are comparable in wild-type (WT) and CCK-AR–/– (knockout, or KO) mice (see text). The pancreatic histology that is shown is representative of sections from five age-matched pairs (WT and CCK-AR–/–) of male mice. (b) Blood glucose levels in CCK-AR–/– mice are not significantly different from the respective values of age- and sex-matched wild-type controls. Morning glucose levels were determined in freely fed mice. Average age and number of animals in the corresponding groups were as follows: 311 ± 53 days (12 wild-type males); 286 ± 57 days (10 CCK-AR–/– males); 307 ± 54 days (15 wild-type females); 330 ± 54 days (14 CCK-AR–/– females). Data are given as mean ± SD. Student's t values for glucose comparisons between wild-type and CCK-AR–/– mice were: t(20) = 0.27, P = 0.79 (males); t(27) = 1.46, P = 0.16 (females).