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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Neurosci. 2014 Jan 28;17(2):183–191. doi: 10.1038/nn.3629

Figure 3. Spinal microcicuitry underlying tactile allodynia associated with neuropathic pain.

Figure 3

Spinal lamina I output neurons do not receive direct input from low-threshold (Aβ) afferents. Yet a polysynaptic pathway indirectly links Aβ fibers to lamina I neurons. The link is normally repressed by inhibitory interneurons (left). After nerve injury, impaired inhibition unmasks the interconnection thus enabling low-threshold inputs to drive lamina I projection neurons (right).