Figure 2. Sample Sizes Required per Study Arm to Retain 80% Power to Detect a 40% Reduction in Risk of Treatment for Exacerbation as a Function of Lung Disease Stage and Study Duration.

Panel A: Sample sizes required to detect a reduction in treatment with “any” antibiotics. Panel B: Sample sizes required to detect a reduction in treatment with IV antibiotics. Note that the scale of the vertical axis of panel B is twice the magnitude of that of panel A.