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. Author manuscript; available in PMC: 2014 Jul 2.
Published in final edited form as: J Cyst Fibros. 2010 Jun 19;9(5):332–338. doi: 10.1016/j.jcf.2010.05.004

Figure 3. Effect of stratification by age and pulmonary function on rate of decline and sample size requirements.

Figure 3

Panel A, mean rates of FEV1 change when measured semiannually over 1.5 years for 2,369 subjects stratified by age and pulmonary function. Bars represent standard errors. Panel B, number of subjects required per arm to detect a 50% treatment effect in a 1:1 study with 80% power (α = 0.05) in the same population.