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. 2014 Apr 23;45(1):439–447. doi: 10.3892/ijo.2014.2396

Figure 1.

Figure 1.

ATN-224 effects the mitochondria. (A) Immunoblots showing Mcl-1, Bcl-2 and Bcl-xL protein levels in SUDHL-4, SUDHL-8 and SUDHL-10 cells. Immunoblots showing actin protein levels to demonstrate similar loading. (B) JC-1 aggregates (ΔΨm) in SUDHL-4, SUDHL-8 and SUDHL-10 cells treated with vehicle or ATN-224 (EC50) for 12 h. All values are mean ± SEM (n ≥3). *p≤0.05, significantly different from vehicle treated control cells. (C) Immunoblots showing Mcl-1, Bcl-2 and Bcl-xL protein levels in SUDHL-4, SUDHL-8 and SUDHL-10 cells treated with vehicle or ATN-224 (EC50) for 24 and 48 h. Immunoblots showing actin protein levels to demonstrate similar loading. (D) Immunoblots showing relative Bak, Bax, Bim, Noxa and Bid protein levels. Immunoblots showing actin as a loading control. All immunoblots are representative blots from three independent sample collections.